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1

Antisense Oligonucleotide Therapies for Neurodegenerative Diseases

Bennett, C. Frank, Krainer, Adrian R., Cleveland, Don W.

Journal:

Annual Review of Neuroscience

Year:

2019

Language:

english

File:

PDF, 772 KB

english, 2019

2

SnapShot: Splicing Alterations in Cancer

Rahman, Mohammad Alinoor, Krainer, Adrian R., Abdel-Wahab, Omar

Journal:

Year:

2020

Language:

english

File:

PDF, 2.43 MB

english, 2020

3

Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice

Sinha, Rahul, Kim, Young Jin, Nomakuchi, Tomoki, Sahashi, Kentaro, Hua, Yimin, Rigo, Frank, Bennett, C Frank, Krainer, Adrian R

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 5.11 MB

english, 2018

4

LISTENING TO SILENCE AND UNDERSTANDING NONSENSE: EXONIC MUTATIONS THAT AFFECT SPLICING

Cartegni, Luca, Chew, Shern L., Krainer, Adrian R.

Journal:

Nature Reviews Genetics

Year:

2002

Language:

english

File:

PDF, 2.83 MB

english, 2002

5

A generalizable pre-clinical research approach for orphan disease therapy

Chandree L Beaulieu, Mark E Samuels, Sean Ekins, Christopher R McMaster, Aled M Edwards, Adrian R Krainer, Geoffrey G Hicks, Brendan J Frey, Kym M Boycott, Alex E MacKenzie

Journal:

Orphanet Journal of Rare Diseases

Year:

2012

Language:

english

File:

PDF, 297 KB

english, 2012

6

S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1

Ben-Hur, Vered, Denichenko, Polina, Siegfried, Zahava, Maimon, Avi, Krainer, Adrian, Davidson, Ben, Karni, Rotem

Journal:

Year:

2013

Language:

english

File:

PDF, 2.24 MB

english, 2013

7

Antisense oligonucleotide–directed inhibition of nonsense-mediated mRNA decay

Nomakuchi, Tomoki T, Rigo, Frank, Aznarez, Isabel, Krainer, Adrian R

Journal:

Nature Biotechnology

Year:

2015

Language:

english

File:

PDF, 700 KB

english, 2015

8

Cation-Induced Stabilization and Denaturation of DNA Origami Nanostructures in Urea and Guanidinium Chloride

Ramakrishnan, Saminathan, Krainer, Georg, Grundmeier, Guido, Schlierf, Michael, Keller, Adrian

Journal:

Year:

2017

Language:

english

File:

PDF, 860 KB

english, 2017

9

Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1

Andrea Zatkova, Ludwine Messiaen, Ina Vandenbroucke, Rotraud Wieser, Christa Fonatsch, Adrian R. Krainer, Katharina Wimmer

Journal:

Year:

2004

Language:

english

File:

PDF, 277 KB

english, 2004

10

Functional significance of a deep intronic mutation in the ATM gene and evidence for an alternative exon 28a

Gabriela Coutinho, Jiuyong Xie, Liutao Du, Alfredo Brusco, Adrian R. Krainer, Richard A. Gatti

Journal:

Year:

2005

Language:

english

File:

PDF, 198 KB

english, 2005

11

A mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia

Tomoya Kubota, Xavier Roca, Takashi Kimura, Yosuke Kokunai, Ichizo Nishino, Saburo Sakoda, Adrian R. Krainer, Masanori P. Takahashi

Journal:

Year:

2011

Language:

english

File:

PDF, 414 KB

english, 2011

12

Antisense oligonucleotide-induced alternative splicing of theAPOBmRNA generates a novel isoform of APOB

Bernard Khoo, Xavier Roca, Shern L Chew, Adrian R Krainer

Journal:

BMC Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.42 MB

english, 2007

13

Short/branched-chain acyl-CoA dehydrogenase deficiency due to an IVS3+3A>G mutation that causes exon skipping

Pia Pinholt Madsen, Maria Kibæk, Xavier Roca, Ravi Sachidanandam, Adrian R. Krainer, Ernst Christensen, Robert D. Steiner, K. Michael Gibson, Thomas J. Corydon, Inga Knudsen, Ronald J.A. Wanders, Jos

Journal:

Year:

2006

Language:

english

File:

PDF, 345 KB

english, 2006

14

10.1038/83762

Krainer, Adrian R., Liu, Hong-Xiang, Cartegni, Luca, Zhang, Michael Q.

Journal:

Nature Genetics

Year:

2001

Language:

english

File:

PDF, 85 KB

english, 2001

15

A splicing component adapted to gene silencing

Roca, Xavier, Krainer, Adrian R

Journal:

Nature Biotechnology

Year:

2009

Language:

english

File:

PDF, 153 KB

english, 2009

16

Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1

Cartegni, Luca, Krainer, Adrian R.

Journal:

Nature Genetics

Year:

2002

Language:

english

File:

PDF, 671 KB

english, 2002

17

Correction of disease-associated exon skipping by synthetic exon-specific activators

Cartegni, Luca, Krainer, Adrian R.

Journal:

Natural Structural Biology

Year:

2003

Language:

english

File:

PDF, 854 KB

english, 2003

18

Recognition of atypical 5′ splice sites by shifted base-pairing to U1 snRNA

Roca, Xavier, Krainer, Adrian R

Journal:

Nature Structural and Molecular Biology

Year:

2009

Language:

english

File:

PDF, 697 KB

english, 2009

19

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control

Sun, Shuying, Zhang, Zuo, Sinha, Rahul, Karni, Rotem, Krainer, Adrian R

Journal:

Nature Structural and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

20

Alternative splicing regulation by interaction of phosphatase PP2Cγ with nucleic acid–binding protein YB-1

Allemand, Eric, Hastings, Michelle L, Murray, Michael V, Myers, Michael P, Krainer, Adrian R

Journal:

Nature Structural and Molecular Biology

Year:

2007

Language:

english

File:

PDF, 372 KB

english, 2007

21

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

Karni, Rotem, de Stanchina, Elisa, Lowe, Scott W, Sinha, Rahul, Mu, David, Krainer, Adrian R

Journal:

Nature Structural and Molecular Biology

Year:

2007

Language:

english

File:

PDF, 455 KB

english, 2007

22

An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites

Hastings, Michelle L, Resta, Nicoletta, Traum, Daniel, Stella, Alessandro, Guanti, Ginevra, Krainer, Adrian R

Journal:

Nature Structural and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 303 KB

english, 2004

23

The pathology of pre-mRNA splicing: a meeting in the Italian Alps. Workshop on Pre-mRNA Processing and Disease

Caceres, Javier F, Krainer, Adrian R, Kornblihtt, Alberto R

Journal:

Year:

2007

Language:

english

File:

PDF, 269 KB

english, 2007

24

hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing

Caputi, Massimo, Mayeda, Akila, Krainer, Adrian R., Zahler, Alan M.

Journal:

The EMBO Journal

Year:

1999

Language:

english

File:

PDF, 225 KB

english, 1999

25

Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch

Hou, Victor C, Lersch, Robert, Gee, Sherry L., Ponthier, Julie L., Lo, Annie J., Wu, Michael, Turck, Chris W., Koury, Mark, Krainer, Adrian R., Mayeda, Akila

Journal:

The EMBO Journal

Year:

2002

Language:

english

File:

PDF, 298 KB

english, 2002

26

Pre-mRNA splicing by complementation with purified human UI, U2, U4/U6 and U5 snRNPs

Krainer, Adrian R.

Journal:

Nucleic Acids Research

Year:

1988

Language:

english

File:

PDF, 3.69 MB

english, 1988

27

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

Kole, Ryszard, Krainer, Adrian R., Altman, Sidney

Journal:

Nature Reviews Drug Discovery

Year:

2012

Language:

english

File:

PDF, 847 KB

english, 2012

28

Human p32: A Coactivator for Epstein–Barr Virus Nuclear Antigen-1-Mediated Transcriptional Activation and Possible Role in Viral Latent Cycle DNA Replication

Sarah Van Scoy, Ikuko Watakabe, Adrian R. Krainer, Janet Hearing

Journal:

Year:

2000

Language:

english

File:

PDF, 368 KB

english, 2000

29

Mechanisms for selecting 5′ splice sites in mammalian pre-mRNA splicing

David S. Horowitz, Adrian R. Krainer

Journal:

Trends in Genetics

Year:

1994

Language:

english

File:

PDF, 1.03 MB

english, 1994

30

A Positive Modifier of Spinal Muscular Atrophy in the SMN2 Gene

Thomas W. Prior, Adrian R. Krainer, Yimin Hua, Kathryn J. Swoboda, Pamela C. Snyder, Scott J. Bridgeman, Arthur H.M. Burghes, John T. Kissel

Journal:

The American Journal of Human Genetics

Year:

2009

Language:

english

File:

PDF, 454 KB

english, 2009

31

Evolutionary impact of limited splicing fidelity in mammalian genes

Chaolin Zhang, Adrian R. Krainer, Michael Q. Zhang

Journal:

Trends in Genetics

Year:

2007

Language:

english

File:

PDF, 701 KB

english, 2007

32

Characterization of a SR protein from Trypanosoma brucei with homology to RNA-binding cis-splicing proteins

Naı̈ma Ismaı̈li, David Pérez-Morga, Patrick Walsh, Akila Mayeda, Annette Pays, Patricia Tebabi, Adrian R. Krainer, Etienne Pays

Journal:

Molecular and Biochemical Parasitology

Year:

1999

Language:

english

File:

PDF, 1.33 MB

english, 1999

33

Pre-mRNA splicing in the new millennium

Michelle L Hastings, Adrian R Krainer

Journal:

Current Opinion in Cell Biology

Year:

2001

Language:

english

File:

PDF, 1.31 MB

english, 2001

34

Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs

Rui-Ming Xu, Lana Jokhan, Xiaodong Cheng, Akila Mayeda, Adrian R Krainer

Journal:

Year:

1997

Language:

english

File:

PDF, 1.35 MB

english, 1997

35

Antisense Masking of an hnRNP A1/A2 Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice

Yimin Hua, Timothy A. Vickers, Hazeem L. Okunola, C. Frank Bennett, Adrian R. Krainer

Journal:

The American Journal of Human Genetics

Year:

2008

Language:

english

File:

PDF, 1.56 MB

english, 2008

36

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

Shipra Das, Olga Anczuków, Martin Akerman, Adrian R. Krainer

Journal:

Year:

2012

Language:

english

File:

PDF, 949 KB

english, 2012

37

Involvement of SR Proteins in mRNA Surveillance

Zuo Zhang, Adrian R. Krainer

Journal:

Year:

2004

Language:

english

File:

PDF, 477 KB

english, 2004

38

SR Proteins Function in Coupling RNAP II Transcription to Pre-mRNA Splicing

Rita Das, Jiong Yu, Zuo Zhang, Melanie P. Gygi, Adrian R. Krainer, Steven P. Gygi, Robin Reed

Journal:

Year:

2007

Language:

english

File:

PDF, 1.14 MB

english, 2007

39

A Splicing-Independent Function of SF2/ASF in MicroRNA Processing

Han Wu, Shuying Sun, Kang Tu, Yuan Gao, Bin Xie, Adrian R. Krainer, Jun Zhu

Journal:

Year:

2010

Language:

english

File:

PDF, 756 KB

english, 2010

40

Palaeoecology of an Early Permian playa lake trace fossil assemblage from Castle Peak, Texas, USA

Nicholas J. Minter, Karl Krainer, Spencer G. Lucas, Simon J. Braddy, Adrian P. Hunt

Journal:

Palaeogeography, Palaeoclimatology, Palaeoecology

Year:

2007

Language:

english

File:

PDF, 8.71 MB

english, 2007

41

Exon Identity Established through Differential Antagonism between Exonic Splicing Silencer-Bound hnRNP A1 and Enhancer-Bound SR Proteins

Jun Zhu, Akila Mayeda, Adrian R. Krainer

Journal:

Year:

2001

Language:

english

File:

PDF, 311 KB

english, 2001

42

BRCA2 T2722R Is a Deleterious Allele That Causes Exon Skipping

James D. Fackenthal, Luca Cartegni, Adrian R. Krainer, Olufunmilayo I. Olopade

Journal:

The American Journal of Human Genetics

Year:

2002

Language:

english

File:

PDF, 435 KB

english, 2002

43

Determinants of Exon 7 Splicing in the Spinal Muscular Atrophy Genes, SMN1 and SMN2

Luca Cartegni, Michelle L. Hastings, John A. Calarco, Elisa de Stanchina, Adrian R. Krainer

Journal:

The American Journal of Human Genetics

Year:

2006

Language:

english

File:

PDF, 1.17 MB

english, 2006

44

Seemingly Neutral Polymorphic Variants May Confer Immunity to Splicing-Inactivating Mutations: A Synonymous SNP in Exon 5 of MCAD Protects from Deleterious Mutations in a Flanking Exonic Splicing Enhancer

Karsten Bork Nielsen, Suzette Sørensen, Luca Cartegni, Thomas Juhl Corydon, Thomas Koed Doktor, Lisbeth Dahl Schroeder, Line Sinnathamby Reinert, Orly Elpeleg, Adrian R. Krainer, Niels Gregersen, Jørg

Journal:

The American Journal of Human Genetics

Year:

2007

Language:

english

File:

PDF, 1.41 MB

english, 2007

45

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

Barbara Ruskin, Adrian R. Krainer, Tom Maniatis, Michael R. Green

Journal:

Year:

1984

Language:

english

File:

PDF, 3.57 MB

english, 1984

46

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

Adrian R. Krainer, Greg C. Conway, Diane Kozak

Journal:

Year:

1990

Language:

english

File:

PDF, 2.00 MB

english, 1990

47

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

Adrian R. Krainer, Akila Mayeda, Diane Kozak, Georgia Binns

Journal:

Year:

1991

Language:

english

File:

PDF, 2.07 MB

english, 1991

48

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

Akila Mayeda, Adrian R. Krainer

Journal:

Year:

1992

Language:

english

File:

PDF, 2.27 MB

english, 1992

49

Splicing-Factor Oncoprotein SRSF1 Stabilizes p53 via RPL5 and Induces Cellular Senescence

Fregoso, Oliver I., Das, Shipra, Akerman, Martin, Krainer, Adrian R.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

50

HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism

Weyn-Vanhentenryck, Sebastien M., Mele, Aldo, Yan, Qinghong, Sun, Shuying, Farny, Natalie, Zhang, Zuo, Xue, Chenghai, Herre, Margaret, Silver, Pamela A., Zhang, Michael Q., Krainer, Adrian R., Darnell

Journal:

Year:

2014

Language:

english

File:

PDF, 2.46 MB

english, 2014

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